Exposure to EDCs can yield lasting effects that persist throughout multiple generations.

Endocrine disrupting chemicals (EDCs) mimic endogenous hormones and disrupt physiological processes under hormonal control. Although emerging research suggests that exposure to EDCs can induce long-term diseases in human and non-human vertebrates, our understanding of the mechanisms underlying these effects are understudied.

My study uses an emerging model system, the self-fertilizing Mangrove killifish (Kryptolebias marmoratus). Mangrove killifish are one of the only vertebrate species that can produce clonal offspring, which enables us to examine multi- and transgenerational effects of EDC exposure independent of genetic variation. Furthermore, by using multiple genetically distinct yet isogenic lineages of Mangrove killifish, we can examine gene x environment interactions, exploring the relationship between genetic variation, environmental exposures, and long-term health deficits.

This proposed work will have broad implications for biomarkers discovery and identification of gene x environment interactions using an innovative research model, corroborating human studies with robust research strategies to inform and address environmental health challenges.